1-DAY ACUVUE^® MOIST

_{Packing solution contains boric acid and disodium tetraborate (sodium borate) to control the pH of the solution.}

_{^ Based on in-vitro data, clinical studies have not been done directly linking differences in lysozyme profile with specific clinical benefits.}

_{^^ In a year-long observational/surveillance registry that relied on patient reports of symptomatic adverse events that would have led them to seek clinical care, no symptomatic infiltrative events or serious adverse events were reported. These results should be considered in conjunction with other clinical  results on the safety and efficacy of daily disposable etafilcon A contact lenses, which also generally show low rates of such events. Although no symptomatic infiltrative events were reported in this study, such events can and have occurred with daily disposable lenses, including 1-DAY ACUVUE^® MOIST, as noted in the product labeling.}

_{** All ACUVUE^® Brand Contact Lenses have Class 1 or Class 2 UV-blocking to help provide protection against transmission of harmful UV radiation to the cornea and into the eye. UV-absorbing contact lenses are NOT substitutes for protective UV-absorbing eyewear such as UV-absorbing goggles or sunglasses because they do not completely cover the eye and surrounding area. UV transmission measured with -1.00D lens.}

_{1. JJV Data on File 2021. Dual Action Technology and “cushion of moisture” description for 1-DAY ACUVUE^® MOIST Brand Family of Contact Lenses.}

_{2. JJV Data on File 2020. ACUVUE^® Brand - EYE-INSPIRED^TM Innovations.}

_{3. 14 clinical studies posted on ClinicalTrials.gov, a website maintained by the NIH, evaluated subjective comfort as a primary or secondary endpoint for 1-DAY ACUVUE^® MOIST brand family (spherical, astigmatism, and multifocal) contact lenses vs. competitors’ products. Published trials include comparisons between etafilcon A and nelfilcon A, omafilcon A, hilafilcon B, ocufilcon D and nesofilcon A. Review conducted as of October 31, 2022.competitors’ products. Review conducted as of October 31, 2022.}

_{4. JJV Data on File 2018. Similarities between Mucin and Poly(N-Vinyl Pyrrolidone) (PVP).}

_{5. JJV Data on File 2018. Dual Action Technology and "Cushion of Moisture" Description for 1-DAY ACUVUE^® MOIST Brand Family of Contact Lenses.}

_{6. Omali NB, Subbaraman L, Heynen M, et al. Surface versus bulk activity of lysozyme deposited on hydrogel contact lens materials in vitro. Contact Lens Anterior Eye. 2018;41(4):329-334.doi: 10.1016/j.clae.2018.03.005.}

_{7. JJV Data on File, 2022. 1-DAY ACUVUE^® MOIST Claims from the TEMPO Observational Registry}